Fisioterapia em Nefrologia

EFFECTS OF AN INTRADIALYTIC RESISTANCE EXERCISE PROGRAM ON: OXIDATIVE STRESS, INFLAMMATION AND QUALITY OF LIFE, IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Francine J. S. C. Sampaio; Laura Severo da Cunha; Renata Ramos; Rejane Oliveira; Andressa Van Grol; Caroline Cantaluppi; Joseane Bohm; Taís Sipriani; Adriane Belló-klein; Joíza Camargo, Sofia Scomazzoni; Fernando Saldanha Thomé.

ABSTRACT

Overall objective: To evaluate the effects of an intradialytic peripheral muscle strengthening program on quality of life, biochemical parameters of inflammation and oxidative stress. Methods: Open randomized controlled trial, with a sample of 23 patients, divided into control group (CG) and intervention group (IG).Both groups had biochemical analysis of inflammation (C-reactive protein) and oxidative stress (malondialdehyde and carbonyls), muscle strength (1RM) test for quadriceps and quality of life questionnaire (KDQOL) performed before and after the experimental period. The program consisted of stretching and strengthening exercises of lower limbs using 50% 1RM loads for 30 minutes at a frequency of three times weekly for 12 weeks (3 months). After this period the two groups were reevaluated. Analyses were performed in SPSS version 17 software using the Generalized Estimating Equations (GEE) for statistical analysis. Results: The IG group showed significant improvement in some of the KDQOL scores (general health, social support, mental health, effects of Chronic Kidney Disease (CKD)) and peripheral muscle strength (p <0.001), but no significant results were found regarding C - reactive protein, Malondialdehyde and Carbonyls. Conclusion: An effective training program for strenghtening of lower limbs did not change oxidative stress parameters or C-reactive protein, but improved quality of life.

Keywords: Chronic kidney disease, Hemodialysis, Inflammation, Oxidative Stress, Peripheral muscle strengthening, Quality of life.